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Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.

Abstract:

The human genome encodes five nonpolymorphic major histocompatibility complex class I-like glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T lymphocytes. Using single alkyl chain detergents, we developed a protocol to generate recombinant human CD1b-lipid complexes. We present here the crystal structures of CD1b in complex with either phosphatidylinositol or ganglioside GM2 at 2.3 A and 2.8 A resolutions, respectively. The antigen-binding groove houses fou...

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Publication status:
Published

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Publisher copy:
10.1038/ni821

Authors


Gadola, SD More by this author
Zaccai, NR More by this author
Shepherd, D More by this author
Castro-Palomino, JC More by this author
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Journal:
Nature immunology
Volume:
3
Issue:
8
Pages:
721-726
Publication date:
2002-08-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:1ee79dcd-69b4-46a1-9bd3-503260a1ba11
Source identifiers:
31194
Local pid:
pubs:31194

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