The human genome encodes five nonpolymorphic major histocompatibility complex class I-like glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T lymphocytes. Using single alkyl chain detergents, we developed a protocol to generate recombinant human CD1b-lipid complexes. We present here the crystal structures of CD1b in complex with either phosphatidylinositol or ganglioside GM2 at 2.3 A and 2.8 A resolutions, respectively. The antigen-binding groove houses fou...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
If you are the owner of this record, you can report an update to it here: Report update to this record