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Effect of in vivo gene transfer of nNOS in the PVN on renal nerve discharge in rats.

Abstract:

The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in the control of sympathetic outflow. Nitric oxide (NO) has been shown to have a sympathoinhibitory effect in the PVN. The goal of the present study was to examine the influence of overexpression of neuronal NO synthase (nNOS) within the PVN on renal sympathetic nerve discharge (RSND). Adenovirus vectors encoding either nNOS (Ad.nNOS) or beta-galactosidase (Ad.beta-Gal) were transfected into the PVN in vivo. Initia...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00503.2001

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Zucker, IH More by this author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
282
Issue:
2
Pages:
H594-H601
Publication date:
2002-02-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:1ee0a4fe-a256-4834-b4f6-48acadfa205b
Source identifiers:
105020
Local pid:
pubs:105020

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