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A stereoselective oxy-Michael route to protected beta-aryl-beta-hydroxy-alpha-amino acids

Abstract:
The stereoselective oxy-Michael addition of the 'naked' anion of (5)-6-methyl tetrahydropyran-2-ol to α-nitro-α,β-unsaturated esters followed by reduction and in situ protection of the corresponding amine provides a new and efficient route to protected β-aryl-β-hydroxy- α-amino acids. © Georg Thieme Verlag Stuttgart.
Publication status:
Published

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Publisher copy:
10.1055/s-2006-950434

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
SYNLETT
Volume:
2006
Issue:
16
Pages:
2673-2675
Publication date:
2006-10-04
DOI:
EISSN:
1437-2096
ISSN:
0936-5214
URN:
uuid:1ee07bb2-64ae-44cd-b222-d5d36a3ddda7
Source identifiers:
40127
Local pid:
pubs:40127

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