- Abstract:
-
Chronic glucocorticoid therapy causes rapid bone loss and clinical osteoporosis. We found that although the glucocorticoid, dexamethasone, stimulated osteoblast maturation, it also inhibited proliferation of a preosteoblastic cell line, MBA-15.4. The dexamethasone-induced decline in preosteoblast proliferation correlated with a 30-40% reduction in protein kinase C/TPA-stimulated mitogen-activated protein kinase (MAPK) activity. These steroid effects only became evident after 6-24 h treatment,...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1210/en.139.5.2423
-
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- Journal:
- Endocrinology
- Volume:
- 139
- Issue:
- 5
- Pages:
- 2423-2431
- Publication date:
- 1998-05-05
- DOI:
- EISSN:
-
1945-7170
- ISSN:
-
0013-7227
- URN:
-
uuid:1edd8425-178c-4e6b-96c8-57b096777a95
- Source identifiers:
-
107548
- Local pid:
- pubs:107548
- Language:
- English
- Keywords:
- Copyright date:
- 1998
Journal article
Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases.
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