Journal article
Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones.
- Abstract:
-
The binding of nominal antigen to Ti alpha-beta heterodimers on MHC-restricted human T cell clones specific for fluorescein-5-isothiocyanate (FL) was detected by flow cytometry and affinity chromatography. The FL-Ti interaction is of physiologic significance, since T cell activation is induced by cross-linked arrays of FL in the absence of the specific MHC recognition. High antigen valence is required to achieve stable binding to cells and subsequent activation, which is consistent with estim...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0092-8674(86)90439-3
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Bibliographic Details
- Journal:
- Cell
- Volume:
- 47
- Issue:
- 2
- Pages:
- 161-171
- Publication date:
- 1986-10-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
31049
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:31049
- UUID:
-
uuid:1ecef618-817c-4bf1-b683-f432c50729fb
- Local pid:
- pubs:31049
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1986
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