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Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones.

Abstract:

The binding of nominal antigen to Ti alpha-beta heterodimers on MHC-restricted human T cell clones specific for fluorescein-5-isothiocyanate (FL) was detected by flow cytometry and affinity chromatography. The FL-Ti interaction is of physiologic significance, since T cell activation is induced by cross-linked arrays of FL in the absence of the specific MHC recognition. High antigen valence is required to achieve stable binding to cells and subsequent activation, which is consistent with estim...

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Publication status:
Published

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Journal:
Cell
Volume:
47
Issue:
2
Pages:
161-171
Publication date:
1986-10-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
31049

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