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The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.

Abstract:

The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to d...

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Publication status:
Published

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Journal:
British journal of rheumatology
Volume:
37
Issue:
4
Pages:
454-458
Publication date:
1998-04-05
ISSN:
0263-7103
URN:
uuid:1ece3347-93e3-4254-bda6-032f7272da56
Source identifiers:
108831
Local pid:
pubs:108831

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