The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.

Brown, MA; Rudwaleit, M; Pile, KD; Kennedy, LG; Shatford, J; Amos, CI; Siminovitch, K; Rubin, L; Calin, A; Wordsworth, BP

Abstract:

The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to d...

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APA Style

Brown, M. A., Rudwaleit, M., Pile, K. D., Kennedy, L. G., Shatford, J., Amos, C. I., Siminovitch, K., Rubin, L., Calin, A., & Wordsworth, B. P. (1998). The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis. British Journal of Rheumatology, 37(4), 454–458.

MLA Style

Brown, M. A., et al. “The Role of Germline Polymorphisms in the T-Cell Receptor in Susceptibility to Ankylosing Spondylitis.” British Journal of Rheumatology, vol. 37, no. 4, 1998, pp. 454–58.

Chicago Style

Brown, MA, M Rudwaleit, KD Pile, LG Kennedy, J Shatford, CI Amos, K Siminovitch, L Rubin, A Calin, and BP Wordsworth. 1998. “The Role of Germline Polymorphisms in the T-Cell Receptor in Susceptibility to Ankylosing Spondylitis.” British Journal of Rheumatology 37 (4): 454–58.
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