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Distinct modes of signal recognition particle interaction with the ribosome.

Abstract:

Signal recognition particle (SRP), together with its receptor (SR), mediates the targeting of ribosome-nascent chain complexes to the endoplasmic reticulum. Using protein cross-linking, we detected distinct modes in the binding of SRP to the ribosome. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts SR, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to...

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Publisher copy:
10.1126/science.1072366

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Sinning, I More by this author
Dobberstein, B More by this author
Journal:
Science (New York, N.Y.)
Volume:
297
Issue:
5585
Pages:
1345-1348
Publication date:
2002-08-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:1ec91c05-f113-4f57-853b-1306992afbb0
Source identifiers:
255383
Local pid:
pubs:255383

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