- Abstract:
-
Signal recognition particle (SRP), together with its receptor (SR), mediates the targeting of ribosome-nascent chain complexes to the endoplasmic reticulum. Using protein cross-linking, we detected distinct modes in the binding of SRP to the ribosome. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts SR, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to...
Expand abstract - Publisher copy:
- 10.1126/science.1072366
-
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- Journal:
- Science (New York, N.Y.)
- Volume:
- 297
- Issue:
- 5585
- Pages:
- 1345-1348
- Publication date:
- 2002-08-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- URN:
-
uuid:1ec91c05-f113-4f57-853b-1306992afbb0
- Source identifiers:
-
255383
- Local pid:
- pubs:255383
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Distinct modes of signal recognition particle interaction with the ribosome.
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