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Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Abstract:

The development of broad-spectrum metallo-beta-lactamase (MBL) inhibitors is challenging due to structural diversity and differences in metal utilisation by these enzymes. Analysis of structural data, followed by non-denturing mass spectrometric analyses, identified thiols proposed to inhibit representative MBLs from all three sub-classes: B1, B2 and B3. Solution analyses led to the identification of broad spectrum inhibitors, including potent inhibitors of the CphA MBL (Aeromonas hydrophila)...

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Publication status:
Published

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Publisher copy:
10.1039/b802311e

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Journal:
Organic and biomolecular chemistry
Volume:
6
Issue:
13
Pages:
2282-2294
Publication date:
2008-07-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Source identifiers:
34281
Language:
English
Keywords:
Pubs id:
pubs:34281
UUID:
uuid:1ebe6125-b761-4db0-aa41-e19431ec580d
Local pid:
pubs:34281
Deposit date:
2012-12-19

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