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Radiosensitisation in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity

Abstract:

As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitising agents minimally toxic to normal tissues, including bowel and bladder, for such patients. We developed methods to determine normal tissue toxicity severity in intestine and bladder in vivo, using novel radiotherapy techniques on a small animal ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1158/1535-7163.MCT-17-0011

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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University of Oxford More from this funder
Rosetrees Trust More from this funder
Slovene Human Resources Development and Scholarship Fund More from this funder
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Molecular Cancer Therapeutics Journal website
Volume:
17
Issue:
2
Pages:
381-392
Publication date:
2017-08-24
Acceptance date:
2017-07-21
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
Pubs id:
pubs:821008
URN:
uri:1eac41a0-a4c9-4653-8974-65688c372fa8
UUID:
uuid:1eac41a0-a4c9-4653-8974-65688c372fa8
Local pid:
pubs:821008

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