- Abstract:
-
Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF-κB signaling, a crucial mediator of survival and regulator of both osteoclasts and osteoblasts. Here we show that NF-κB repression by SirT1 in both osteoclasts and osteoblasts is necessary for proper bone remodeling and may contribute to the mechanisms linking aging and bone loss. Osteoclast- or osteoblast-specific SirT1 deletion using the Sirt(flox/flox) mice crossed to lysozyme M-cre and the 2.3 kb col...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/jbmr.1824
-
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- Journal:
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Volume:
- 28
- Issue:
- 4
- Pages:
- 960-969
- Publication date:
- 2013-04-05
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- URN:
-
uuid:1eaaebc4-d9aa-4c58-b843-fd727f1d5b3a
- Source identifiers:
-
363841
- Local pid:
- pubs:363841
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.
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