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Journal article

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Abstract:

Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF-κB signaling, a crucial mediator of survival and regulator of both osteoclasts and osteoblasts. Here we show that NF-κB repression by SirT1 in both osteoclasts and osteoblasts is necessary for proper bone remodeling and may contribute to the mechanisms linking aging and bone loss. Osteoclast- or osteoblast-specific SirT1 deletion using the Sirt(flox/flox) mice crossed to lysozyme M-cre and the 2.3 kb col...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.1824

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Perrien, DS More by this author
Fleming, N More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
28
Issue:
4
Pages:
960-969
Publication date:
2013-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:1eaaebc4-d9aa-4c58-b843-fd727f1d5b3a
Source identifiers:
363841
Local pid:
pubs:363841
Language:
English
Keywords:

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