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Initial assessment of a model relating intratumoral genetic heterogeneity to radiological morphology.

Abstract:

Tumour heterogeneity has major implications for tumour development and response to therapy. Tumour heterogeneity results from mutations in the genes responsible for mismatch repair or maintenance of chromosomal stability. Cells with different genetic properties may grow at different rates and exhibit different resistance to therapeutic interventions. To date, there exists no approach to non-invasively assess tumour heterogeneity. Here we present a biologically inspired model of tumour growth,...

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Publication status:
Published

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Publisher copy:
10.1259/bjr/76979647

Authors


Journal:
British journal of radiology More from this journal
Volume:
83
Issue:
986
Pages:
166-170
Publication date:
2010-02-01
DOI:
EISSN:
1748-880X
ISSN:
0007-1285
Language:
English
Keywords:
Pubs id:
pubs:64924
UUID:
uuid:1ea9d978-e4a2-4120-acbd-4c9bdc4461d1
Local pid:
pubs:64924
Source identifiers:
64924
Deposit date:
2012-12-19

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