Journal article icon

Journal article

Molecular and structural analysis of a continuous birch profilin epitope defined by a monoclonal antibody.

Abstract:

The interaction of a mouse monoclonal antibody (4A6) and birch profilin, a structurally well conserved actin- and phosphoinositide-binding protein and cross-reactive allergen, was characterized. In contrast to serum IgE from allergic patients, which shows cross-reactivity with most plants, monoclonal antibody 4A6 selectively reacted with tree pollen profilins. Using synthetic overlapping peptides, a continuous hexapeptide epitope was identified. The exchange of a single amino acid (Gln-47 --&...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.271.47.29915

Authors


Expand authors...
Journal:
Journal of biological chemistry
Volume:
271
Issue:
47
Pages:
29915-29921
Publication date:
1996-11-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
69745
Language:
English
Keywords:
Pubs id:
pubs:69745
UUID:
uuid:1ea4df5e-94f2-47f4-bc43-4a05211839a5
Local pid:
pubs:69745
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP