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Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor.

Abstract:

Calmodulin (CaM) is a ubiquitous Ca2+ sensor protein that plays an important role in regulating a large number of Ca2+ channels, including the inositol 1,4,5-trisphosphate receptor (IP3R). Despite many efforts, the exact mechanism by which CaM regulates the IP3R still remains elusive. Here we show, using unidirectional 45Ca2+ flux experiments on permeabilized L15 fibroblasts and COS-1 cells, that endogenously bound CaM is essential for the proper activation of the IP3R. Removing endogenously ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m510971200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
281
Issue:
13
Pages:
8332-8338
Publication date:
2006-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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