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Journal article

Hypoxia promotes the production and inhibits the destruction of human articular cartilage.

Abstract:

OBJECTIVE: To determine the effects of hypoxia on both anabolic and catabolic pathways of metabolism in human articular cartilage and to elucidate the roles played by hypoxia-inducible factors (HIFs) in these responses. METHODS: Normal human articular cartilage from a range of donors was obtained at the time of above-the-knee amputations due to sarcomas not involving the joint space. Fresh cartilage tissue explants and isolated cells were subjected to hypoxia and treatment with interleukin-1...

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Publication status:
Published

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Publisher copy:
10.1002/art.37867

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Arthritis and rheumatism More from this journal
Volume:
65
Issue:
5
Pages:
1302-1312
Publication date:
2013-05-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591

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