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The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.

Abstract:

This study tested the hypothesis that a set of predominantly myeloid restricted receptors (F4/80, CD36, Dectin-1, CD200 receptor and mannan binding lectins) and the broadly expressed CD200 played a role in a key function of plasmacytoid DC (pDC), virally induced type I interferon (IFN) production. The Dectin-1 ligands zymosan, glucan phosphate and the anti-Dectin-1 monoclonal antibody (mAb) 2A11 had no effect on influenza virus induced IFNα/β production by murine splenic pDC. However, mannan,...

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Publication status:
Published

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Authors


Mukhopadhyay, S More by this author
Miller, JL More by this author
Journal:
International immunopharmacology
Volume:
11
Issue:
7
Pages:
794-801
Publication date:
2011-07-05
DOI:
EISSN:
1878-1705
ISSN:
1567-5769
URN:
uuid:1e9292d2-12d7-4c41-b50e-0b4ab370b3ed
Source identifiers:
115760
Local pid:
pubs:115760

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