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Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment

Abstract:

Dimethylsulfoxide (DMSO) has conventionally been used for cell cryopreservation both in research and in clinical applications, but has long-term cytotoxic effects. Trehalose, a natural disaccharide, has been proposed as a non-toxic cryoprotectant. However, the lack of specific cell membrane transporter receptors inhibits transmembrane transport and severely limits its cryoprotective capability. This research presents a method to successfully deliver trehalose into mesenchymal stem cells (MSCs...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s44172-024-00265-6

Authors


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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0003-1469-2629
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-3245-3296
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-6473-7683
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-5988-9911
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-7021-3886
Publisher:
Nature Research
Journal:
Communications Engineering More from this journal
Volume:
3
Issue:
1
Article number:
129
Publication date:
2024-09-09
Acceptance date:
2024-08-08
DOI:
EISSN:
2731-3395
Language:
English
Source identifiers:
2250948
Deposit date:
2024-09-10
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