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Big brains, meat, tuberculosis, and the nicotinamide switches: co-evolutionary relationships with modern repercussions?

Abstract:

Meat-eating was a game changer for human evolution. We suggest that the limiting factors for expanding brains earlier were scarcities of nicotinamide and tryptophan. In humans and some other omnivores, lack of meat causes these deficiencies. Nicotinamide adenine dinucleotide (NADH) is necessary to synthesize adenosine triphosphate (ATP) via either glycolysis or via the mitochondrial respiratory chain. NAD consumption is also necessary for developmental and repair circuits. Inadequate supplies...

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Publisher copy:
10.4137/ijtr.s12838

Authors


Journal:
International journal of tryptophan research : IJTR
Volume:
6
Pages:
73-88
Publication date:
2013-01-01
DOI:
EISSN:
1178-6469
URN:
uuid:1e7dffea-485f-4178-b2d9-7a7c0567d56d
Source identifiers:
440080
Local pid:
pubs:440080

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