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Journal article

Specific role for cathepsin S in the generation of antigenic peptides in vivo.

Abstract:

To address the role of different proteases in degradation of antigen destined for MHC class II-restricted presentation, we generated cathepsin-deficient mice carrying a transgenic B cell receptor (BCR) specific for hen egg lysozyme (HEL). We demonstrate that degradation of HEL in B lymphocytes is highly processive and does not result in discrete processing intermediates. Moreover, degradation of HEL does not require initial unlocking of the antigen by any of the cathepsins tested. Using mass ...

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Journal:
European journal of immunology
Volume:
32
Issue:
2
Pages:
467-476
Publication date:
2002-02-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
415901

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