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Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study.

Abstract:

MicroRNAs (miRNAs) are post-transcriptional gene regulators involved in a wide range of biological processes including tumorigenesis. Deregulation of miRNA pathways has been associated with cancer but the contribution of their genetic variability to this disorder is poorly known. We analyzed the genetic association of gastric cancer (GC) and its anatomical and histological subtypes, with 133 single-nucleotide polymorphisms (SNPs) tagging 15 isolated miRNAs and 24 miRNA clusters potentially in...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.28850

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Publisher:
Wiley-Liss Inc.
Journal:
International journal of cancer. Journal international du cancer
Volume:
135
Issue:
9
Pages:
2065-2076
Publication date:
2014-11-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
483081

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