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Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.

Abstract:

The chromosomal passenger complex (CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Despite observations that small interfering RNA-mediated knockdown of any one member of the CPC abolishes localization of the other subunits, it remains unclear how the complex is targeted to the centromere. We have now identified a ter...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e05-12-1133

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular biology of the cell More from this journal
Volume:
17
Issue:
6
Pages:
2547-2558
Publication date:
2006-06-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Language:
English
Keywords:
Pubs id:
pubs:196728
UUID:
uuid:1e7108ce-fdb0-427b-8bb2-25fb63da1cf2
Local pid:
pubs:196728
Source identifiers:
196728
Deposit date:
2012-12-19

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