Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

Journal article

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and synovial hyperplasia leading to progressive joint destruction. Fibroblast-like synoviocytes (FLS) are central components of the aggressive, tumour-like synovial structure termed pannus, which invades the joint space and cartilage. A distinct natural killer (NK) cell subset expressing the inhibitory CD94/NKG2A receptor is present in RA synovial fluid. Little is known about possible cellular interaction...

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Authors: Nielsen, N; Pascal, V; Fasth, A; Sundström, Y; Galsgaard, E

• Publication status: Published
• Publisher: Blackwell Publishing Ltd
• Journal: Immunology
• Volume: 142
• Issue: 4
• Pages: 581-593
• Publication date: 2014-08-01
• DOI: 10.1111/imm.12271
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Up-Regulation; Cell Degranulation; Natural Cytotoxicity Triggering Receptor 2; Female; Synovial Membrane; Antigens, Differentiation, T-Lymphocyte; Cell Line; Male; Arthritis, Rheumatoid; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 1; NK Cell Lectin-Like Receptor Subfamily D; Humans; Histocompatibility Antigens Class I; NK Cell Lectin-Like Receptor Subfamily C; Fibroblasts; NK Cell Lectin-Like Receptor Subfamily K