Journal article icon

Journal article

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

Abstract:

We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in MAP3K15 were 30% less likely to develop diabetes (P = 5.7 × 10−10) and had lower glycosylated hemoglobin (β = −0.14 SD units, P = 1.1 × 10−24). These associations were independent of body mass index, suggesting protectio...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1126/sciadv.add5430

Authors


More by this author
Role:
Author
ORCID:
0000-0002-4638-2433
More by this author
Role:
Author
ORCID:
0000-0002-8965-0813
More by this author
Role:
Author
ORCID:
0000-0003-4558-4698
Publisher:
American Association for the Advancement of Science
Journal:
Science Advances More from this journal
Volume:
8
Issue:
46
Article number:
eadd5430
Publication date:
2022-11-16
Acceptance date:
2022-09-27
DOI:
EISSN:
2375-2548
Language:
English
Keywords:
Pubs id:
1304873
Local pid:
pubs:1304873
Deposit date:
2022-11-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP