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Improved therapeutic antibody delivery to xenograft tumors using cavitation nucleated by gas-entrapping nanoparticles

Abstract:

Aims: Testing ultrasound-mediated cavitation for enhanced delivery of the therapeutic antibody cetuximab to tumors in a mouse model.

Methods: Tumors with strong EGF receptor expression were grown bilaterally. Cetuximab was coadministered intravenously with cavitation nuclei, consisting of either the ultrasound contrast agent Sonovue or gas-stabilizing nanoscale SonoTran Particles. One of the two tumors was exposed to focused ultrasound. Passive aco...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2217/nnm-2020-0263

Authors


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Role:
Author
ORCID:
0000-0001-9523-3066
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-4882-1356
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-0676-6889
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Name:
Engineering & Physical Sciences Research Council
Grant:
EP/L024012/1
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Name:
Engineering and Physical Sciences Research Council
Publisher:
Future Medicine
Journal:
Nanomedicine More from this journal
Volume:
16
Issue:
1
Pages:
37-50
Publication date:
2021-01-11
Acceptance date:
2020-11-04
DOI:
EISSN:
1748-6963
ISSN:
1743-5889
Pmid:
33426913
Language:
English
Keywords:
Pubs id:
1156553
Local pid:
pubs:1156553
Deposit date:
2022-11-04

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