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Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes

Abstract:

In Trypanosoma brucei, glycosylphosphatidylinositol phospholipase C (GPI-PLC) is a virulence factor that releases variant surface glycoprotein (VSG) from dying cells. In live cells, GPI-PLC is localised to the plasma membrane where it is concentrated on the flagellar membrane, so activity or access must be tightly regulated as very little VSG is shed. Little is known about regulation except that acylation within a short internal motif containing three cysteines is necessary for GPI-PLC to acc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1003566

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
9
Issue:
8
Pages:
e1003566-e1003566
Publication date:
2013-01-01
DOI:
EISSN:
1553-7374
URN:
uuid:1e665f32-88b7-4ec9-b4f9-fa4cb0ab4a20
Source identifiers:
608954
Local pid:
pubs:608954

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