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Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols

Abstract:
Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. An in silico reconstruction of the effect of drugs on the cardiac action potential forms an integral part of the Comprehensive in vitro Proarrhythmia Assay (CiPA) strategy.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vascn.2017.09.089

Authors


Beattie, KA More by this author
Bardenet, R More by this author
Louttit, JB More by this author
Vandenberg, JI More by this author
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Publisher:
Elsevier Publisher's website
Volume:
88
Issue:
2
Pages:
195-196
Publication date:
2017-11-03
DOI:
EISSN:
1873-488X
ISSN:
1056-8719
Pubs id:
pubs:811922
URN:
uri:1e63e5ee-807a-428d-aa38-557e49a64477
UUID:
uuid:1e63e5ee-807a-428d-aa38-557e49a64477
Local pid:
pubs:811922

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