Journal article icon

Journal article

Pyogenic bacterial infections in humans with MyD88 deficiency.

Abstract:

MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patien...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1126/science.1158298

Authors


Expand authors...
Journal:
Science (New York, N.Y.)
Volume:
321
Issue:
5889
Pages:
691-696
Publication date:
2008-08-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
66848

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP