Journal article
Pyogenic bacterial infections in humans with MyD88 deficiency.
- Abstract:
-
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patien...
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- Publication status:
- Published
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- Publisher copy:
- 10.1126/science.1158298
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Authors
Bibliographic Details
- Journal:
- Science (New York, N.Y.)
- Volume:
- 321
- Issue:
- 5889
- Pages:
- 691-696
- Publication date:
- 2008-08-01
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Source identifiers:
-
66848
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:66848
- UUID:
-
uuid:1e60df7a-baf4-4a83-a265-89dcf4cc3036
- Local pid:
- pubs:66848
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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