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In vitro tests of natural allelic variation of innate immune genes (avian β-defensins) reveal functional differences in microbial inhibition.

Abstract:

Allelic variation in immune genes might result from, and contribute to, host-pathogen evolution. Functional allelic variation in the innate immune system has received little attention. Here, we investigate whether naturally occurring allelic variation within the avian innate immune system (β-defensins) is associated with variation in antimicrobial activity. We tested differences in in vitro antimicrobial properties of the synthesized products of two alleles of avian β-defensin 7, both of whic...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Journal of evolutionary biology More from this journal
Volume:
23
Issue:
12
Pages:
2726-2730
Publication date:
2010-12-01
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
Language:
English
Keywords:
Pubs id:
pubs:204455
UUID:
uuid:1e5c29a6-f9b9-4515-9ca2-b99fb4a1a5d5
Local pid:
pubs:204455
Source identifiers:
204455
Deposit date:
2012-12-19

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