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Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways.

Abstract:

Mucosal Associated Invariant T (MAIT) cells represent an innate T-cell population which can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major-histocompatibility-complex (MHC) class I-related molecule MR1. Streptococcus pneumoniae (the 'pneumococcus') is a major human pathogen that is also associated with commensal carriage, thus host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jix647

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More from this funder
Name:
John Fell Fund
Grant:
123/734
More from this funder
Name:
Cancer Research UK
Grant:
C399/A2291
More from this funder
Name:
National Institutes of Health
Grant:
NIHU19AI082630
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
More from this funder
Name:
National Institute for Health Research
Grant:
NF-SI-0515-10005
Publisher:
Oxford University Press
Journal:
Journal of Infectious Diseases More from this journal
Volume:
217
Issue:
6
Pages:
988–999
Publication date:
2017-12-01
Acceptance date:
2017-12-14
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
29267892
Language:
English
Keywords:
Pubs id:
pubs:812989
UUID:
uuid:1e524dd0-dbed-4afd-8047-f1ef80c0e640
Local pid:
pubs:812989
Deposit date:
2017-12-29

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