- Abstract:
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Mucosal Associated Invariant T (MAIT) cells represent an innate T-cell population which can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major-histocompatibility-complex (MHC) class I-related molecule MR1. Streptococcus pneumoniae (the 'pneumococcus') is a major human pathogen that is also associated with commensal carriage, thus host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined,...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.0MB)
-
- Publisher copy:
- 10.1093/infdis/jix647
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Volume:
- 217
- Issue:
- 6
- Pages:
- 988–999
- Publication date:
- 2017-12-05
- Acceptance date:
- 2017-12-14
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pubs id:
-
pubs:812989
- URN:
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uri:1e524dd0-dbed-4afd-8047-f1ef80c0e640
- UUID:
-
uuid:1e524dd0-dbed-4afd-8047-f1ef80c0e640
- Local pid:
- pubs:812989
- Language:
- English
- Keywords:
- Copyright holder:
- Klenerman et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways.
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