Journal article icon

Journal article

Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways.

Abstract:

Mucosal Associated Invariant T (MAIT) cells represent an innate T-cell population which can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major-histocompatibility-complex (MHC) class I-related molecule MR1. Streptococcus pneumoniae (the 'pneumococcus') is a major human pathogen that is also associated with commensal carriage, thus host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined,...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1093/infdis/jix647

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
Expand authors...
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
217
Issue:
6
Pages:
988–999
Publication date:
2017-12-05
Acceptance date:
2017-12-14
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:812989
URN:
uri:1e524dd0-dbed-4afd-8047-f1ef80c0e640
UUID:
uuid:1e524dd0-dbed-4afd-8047-f1ef80c0e640
Local pid:
pubs:812989

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP