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Journal article

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.

Abstract:

Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplantation into irradiated or otherwise immunocompromised adult organisms provide long-term reconstitution of the entire hematopoietic system. They emerge in the vertebrate conceptus around midgestation. Genetic studies have identified a number of transcription factors and signaling molecules that act at the onset of hematopoiesis, and have begun to delineate the molecular mechanisms underlying the formation of H...

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Publication status:
Published

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Publisher copy:
10.1387/ijdb.103106gs

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
International journal of developmental biology
Volume:
54
Issue:
6-7
Pages:
1151-1163
Publication date:
2010-01-01
DOI:
EISSN:
1696-3547
ISSN:
0214-6282
Source identifiers:
255081
Language:
English
Keywords:
Pubs id:
pubs:255081
UUID:
uuid:1e4cb1d9-9052-48e9-9196-8c25e4c7e580
Local pid:
pubs:255081
Deposit date:
2012-12-19

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