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A naturally protective epitope of limited variability as an influenza vaccine target

Abstract:

Current antigenic targets for influenza vaccine development are either highly immunogenic epitopes of high variability or conserved epitopes of low immunogenicity. This requires continuous update of the variable epitopes in the vaccine formulation or boosting of immunity to invariant epitopes of low natural efficacy. Here we identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin protein. We show that a cohort of young children exhibit natural ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-06228-8

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
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Funding agency for:
Thompson, C
Grant:
268904-DIVERSITY
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Funding agency for:
Obolski, U
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Funding agency for:
Pybus, O
Grant:
614725-PATHPHYLODYN
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Funding agency for:
Gupta, S
Grant:
268904-DIVERSITY
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Grant:
Translation Award
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
3859
Publication date:
2018-09-21
Acceptance date:
2018-08-06
DOI:
ISSN:
2041-1723
Source identifiers:
897019
Pubs id:
pubs:897019
UUID:
uuid:1e4b4ddb-35a7-47c3-809a-b2d6469d5230
Local pid:
pubs:897019
Deposit date:
2018-08-09

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