- Abstract:
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Current antigenic targets for influenza vaccine development are either highly immunogenic epitopes of high variability or conserved epitopes of low immunogenicity. This requires continuous update of the variable epitopes in the vaccine formulation or boosting of immunity to invariant epitopes of low natural efficacy. Here we identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin protein. We show that a cohort of young children exhibit natural ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.7MB)
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- Publisher copy:
- 10.1038/s41467-018-06228-8
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Pages:
- Article: 3859
- Publication date:
- 2018-09-21
- Acceptance date:
- 2018-08-06
- DOI:
- ISSN:
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2041-1723
- Pubs id:
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pubs:897019
- URN:
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uri:1e4b4ddb-35a7-47c3-809a-b2d6469d5230
- UUID:
-
uuid:1e4b4ddb-35a7-47c3-809a-b2d6469d5230
- Local pid:
- pubs:897019
- Copyright holder:
- Thompson et al.
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Journal article
A naturally protective epitope of limited variability as an influenza vaccine target
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