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German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma.

Abstract:

The prospective multicenter NOA-03 trial, conducted by the Neuro-Oncology Working Group (NOA) of the German Cancer Society, was initiated to define the feasibility and efficacy of single-agent high-dose methotrexate therapy without concomitant radiotherapy in immunocompetent patients with primary central nervous system lymphoma. Thirty-seven patients (median age, 60 years) received 179 biweekly courses of 8 g/m2 methotrexate. Response was assessed after 3 and 6 courses. We had planned to ente...

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Publisher copy:
10.1002/ana.10102

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Journal:
Annals of neurology
Volume:
51
Issue:
2
Pages:
247-252
Publication date:
2002-02-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:1e47c2fc-d9d8-4d00-b2c2-b94648c67096
Source identifiers:
240882
Local pid:
pubs:240882

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