Updated outline 29/12/20

Separate into sections (spatial targeting, temporal targeting, applications)
Separate sections into chapters
Each chapter is standalone "project": report, slides, chapter - plus paper (list target journals & specs for each)
Mix of technical (e.g. IEEE etc.) and scientific / applied work

E.g.:

Section 1: Introduction
Overall intro: spatiotemporal precision & targeted / patient-specific stimulation (+/- neuroprosthetics, scale of issue posed by disability, economic impact of solutions, etc.)
1.1 Disability & functional restoration - scope of problem of disability (?SCI specifically); potential clinical and economic impact of improved methods for restoring function; ?functional restoration broadly - rehab, prosthethics, stimulation, etc.
1.2 Neuroprosthetics for functional restoration - review of neuroprosthetic approaches (neuroprosthetics review)
1.3 Neuromodulation for spinal cord injury repair - review of invasive & noninvasive work in restoring function using spinal cord stimulation; ?systematic review & nervous system repair more broadly - ?incl peripheral nerve repair etc. (e.g. use stim for median nerve repair etc. - neuromodulation as generally useful for functional gain) - would need to determine search terms etc. - will need tight scope etc.; or just non-systematic narrative review?
1.4 Computational methods for targeted neural interfacing - potential of spatiotemporally precise neuromodulation; modeling for spatial precision, control theory for temporal precision + DL etc. for modeling transfer functions, potential applications (brain, spinal cord, peripheral nerves, etc.) (WN column + spatial, temporal, pathology intro)
1.5 Contribution - summarise goal of present thesis & contextualise sections to come: system for spatial precision, methods for precision control, applications to pathology
(?Remove section intros and use one overall intro)

Section 1: Targeted stimulation
Intro: spatial targeting, current modeling methods, etc.
1.1 Solving PDEs on patient-specific models with simulated interventions (transfer topic - incl. validation w/ printed models?) - Generating patient-specific computational models from clinical imaging
1.2 Evaluating the effect of an external electric field on neural tissue
1.3 Optimisation using biologically relevant objective functions
1.4 3D printing for intervention planning - direct multimaterial models from imaging & use
1.5 NRRDosurgery: a generalisable tool for patient-specific stimulation

Section 2: Temporally specific stimulation
Intro: Adaptive / closed-loop stimulation; control of amplitude and frequency, etc.; designing transfer functions
2.1 Stochastic stimulation for freq modulation etc. (check title)
2.2 Control of stimulation output using physiological input (phrenic device / respiratory targeting)
2.3 Control of stimulation output using DL (BCI; complex multichannel data)
2.4 DL on device (embedded system for real-time control of stimulation using complex inputs)

Section 3: Applications
Intro: Applications to pathology: use of technology for new treatment approaches (e.g. WN column, prosthetics, etc.)
3.1 Dorsal column stimulation (modeling, validation, humans possibly)
3.2 Interferential stimulation (modeling, validation, incl. optimisation etc.)
3.3 Phrenic nerve: modeling (spatial, temporal), device design, testing
3.4 Median nerve: review, modeling (spatial), device design, testing
3.5 Sacral nerve roots: Modeling, etc.?
3.6 Other applications? Stellate, auriculotemporal, ?brain, ?others (?include sacrum here)

Overall conclusion: Spatial and temporal targeting for precision neuromodulation & potential impact, including next steps
Section 5: Conclusion
5.1 Neural control systems - computational neurosurgery; use of model-based approach allows control of neural systems, etc.
5.2 Outlook in neurotechnologies - future developments in functional restoration; emerging technologies, clinical trials - broad impact of work
5.3 Conclusion - summary of main points & wrap up, incl. impact
