- Abstract:
-
Enterovirus 71 (HEV71) epidemics in children and infants result mainly in mild symptoms; however, especially in the Asia-Pacific region, infection can be fatal. At present, no therapies are available. We have used structural analysis of the complete virus to guide the design of HEV71 inhibitors. Analysis of complexes with four 3-(4-pyridyl)-2-imidazolidinone derivatives with varying anti-HEV71 activities pinpointed key structure-activity correlates. We then identified additional potentially b...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nsmb.2769
-
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- Publisher:
- Nature Publishing Group
- Journal:
- Nature structural and molecular biology
- Volume:
- 21
- Issue:
- 3
- Pages:
- 282-288
- Publication date:
- 2014-03-05
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- URN:
-
uuid:1e41b39b-61d5-4f2c-8f47-53d3860bb477
- Source identifiers:
-
449122
- Local pid:
- pubs:449122
- Copyright date:
- 2014
Journal article
More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules.
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