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More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules.

Abstract:

Enterovirus 71 (HEV71) epidemics in children and infants result mainly in mild symptoms; however, especially in the Asia-Pacific region, infection can be fatal. At present, no therapies are available. We have used structural analysis of the complete virus to guide the design of HEV71 inhibitors. Analysis of complexes with four 3-(4-pyridyl)-2-imidazolidinone derivatives with varying anti-HEV71 activities pinpointed key structure-activity correlates. We then identified additional potentially b...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.2769

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Publisher:
Nature Publishing Group
Journal:
Nature structural and molecular biology
Volume:
21
Issue:
3
Pages:
282-288
Publication date:
2014-03-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:1e41b39b-61d5-4f2c-8f47-53d3860bb477
Source identifiers:
449122
Local pid:
pubs:449122

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