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Modulation of host immunity by the human metapneumovirus

Abstract:

Globally, as a leading agent of acute respiratory tract infections in children <5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice, the acquired immune response elicited by this pathogen fails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/CMR.00081-15

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Department:
Oxford, Medical Sciences Division, NDORMS, KIR
Role:
Author
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Grant:
National Fund for Scientific and Technological Development (grant no. 1070352, 1140010, and 1150862 and postdoctorate grant no. 3140455); Corporación de Fomento de la Producción (grant no. 11IDL2-10668, 13CTI-21526-P4, and 13CTI-21526-P5); National Corporation of Science and Technology (CTU-06); Iniciativa Científica Milenio (P09-016-F).
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical Microbiology Reviews Journal website
Volume:
29
Issue:
4
Pages:
795-818
Publication date:
2016-07-13
DOI:
ISSN:
0893-8512 and 1098-6618
Pubs id:
pubs:640193
URN:
uri:1e389a8e-69d6-4a09-8381-c22e8fee6aea
UUID:
1e389a8e-69d6-4a09-8381-c22e8fee6aea
Local pid:
pubs:640193
Keywords:

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