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Modulation of host immunity by the human metapneumovirus

Abstract:

Globally, as a leading agent of acute respiratory tract infections in children <5 years of age and the elderly, the human metapneumovirus (HMPV) has gained considerable attention. As inferred from studies comparing vaccinated and experimentally infected mice, the acquired immune response elicited by this pathogen fails to efficiently clear the virus from the airways, which leads to an exaggerated inflammatory response and lung damage. Furthermore, after disease resolution, there is a poor ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/CMR.00081-15

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Grant:
NationalFundforScientific
TechnologicalDevelopment(grantno.1070352,1140010,
13CTI-21526-P5);NationalCorporationofScience
1150862
CorporacióndeFomentodelaProducción(grantno.11IDL2-10668,13CTI-21526-P4,
postdoctorategrantno.3140455)
IniciativaCientíficaMilenio(P09-016-F
Technology(CTU-06
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical Microbiology Reviews Journal website
Volume:
29
Issue:
4
Pages:
795-818
Publication date:
2016-07-13
DOI:
ISSN:
1098-6618 and 0893-8512
Source identifiers:
640193
Keywords:
Pubs id:
pubs:640193
UUID:
uuid:1e389a8e-69d6-4a09-8381-c22e8fee6aea
Local pid:
pubs:640193
Deposit date:
2016-08-23

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