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A novel metal-based imaging probe for targeted dual-modality SPECT/MR imaging of angiogenesis

Abstract:

Superparamagnetic iron oxide nanoparticles with well-integrated multimodality imaging properties have generated increasing research interest in the past decade, especially when it comes to the targeted imaging of tumors. Bevacizumab (BCZM) on the other hand is a well-known and widely applied monoclonal antibody recognizing VEGF-A, which is overexpressed in angiogenesis. The aim of this proof-of-concept study was to develop a dual-modality nanoplatform for in vivo targeted single photon comput...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fchem.2018.00224

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
St Hugh's College
Role:
Author
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Name:
Cancer Research UK
Grant:
18974
Publisher:
Frontiers Media
Journal:
Frontiers in Chemistry More from this journal
Volume:
6
Publication date:
2018-06-20
Acceptance date:
2018-05-30
DOI:
EISSN:
2296-2646
Pmid:
29974048
Language:
English
Keywords:
Pubs id:
pubs:864483
UUID:
uuid:1e3289c7-a887-4d7d-a20f-898e9e24a253
Local pid:
pubs:864483
Source identifiers:
864483
Deposit date:
2018-08-17

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