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Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.

Abstract:

We assessed the safety and immunogenicity of prime-boost vectors encoding the Plasmodium falciparum circumsporozoite (CS) protein expressed either in the attenuated fowl-pox virus (FP9) or modified vaccinia virus Ankara (MVA). Thirty-two adult Gambians in groups of four to eight received one, two or three doses of FP9 CS and/or MVA CS. No serious adverse event was observed following vaccination. The most immunogenic regimen was two doses of FP9 followed by a single dose of MVA 4 weeks later (...

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Publication status:
Published

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Journal:
Vaccine
Volume:
24
Issue:
42-43
Pages:
6526-6533
Publication date:
2006-10-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Source identifiers:
53901

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