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NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer.

Abstract:

NY-CO-58/KIF2C has been identified as a tumor antigen by screening antibody responses in patients with colorectal cancer. However, expression had not consequently been examined, and nothing was known about its ability to induce spontaneous T cell responses, which have been suggested to play a role in the development of colorectal cancer. We analyzed 5 colorectal cancer cell lines, and tumor samples and adjacent healthy tissues from 176 patients with epithelial cancers for the expression of NY...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.25058

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Journal:
International journal of cancer. Journal international du cancer
Volume:
127
Issue:
2
Pages:
381-393
Publication date:
2010-07-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
34989

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