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Journal article

Antibodies in myasthenia gravis and related disorders.

Abstract:

Acetylcholine receptor (AChR) antibodies are present in around 85% of patients with myasthenia gravis (MG) as measured by the conventional radioimmunoprecipitation assay. Antibodies that block the fetal form of the AChR are occasionally present in mothers who develop MG after pregnancy, especially in those whose babies are born with arthrogryposis multiplex congenita. The antibodies cross the placenta and block neuromuscular transmission, leading to joint deformities and often stillbirth. In ...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1254.036

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
McConville, J More by this author
Farrugia, ME More by this author
Plested, P More by this author
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Journal:
Annals of the New York Academy of Sciences
Volume:
998
Issue:
1
Pages:
324-335
Publication date:
2003-09-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:1e1607ec-418b-4234-916c-4127f883be95
Source identifiers:
241141
Local pid:
pubs:241141

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