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Journal article

Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.

Abstract:

The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis in the developing embryo. Here we implicate Hand1 as a molecular switch that determines whether a trophoblast stem cell continues to proliferate or commits to differentiation. We identify a novel interaction of Hand1 with a protein that contains an I-mfa (inhibitor of myogenic factor) domain that anchors Hand1 in the nucleolus where it negatively regulates Hand1 activity. In the trophoblast stem-cell l...

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Publication status:
Published

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Publisher copy:
10.1038/ncb1633

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Nature cell biology More from this journal
Volume:
9
Issue:
10
Pages:
1131-1141
Publication date:
2007-10-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392

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