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Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase

Abstract:

Glucose metabolism is essential for the brain: it not only provides the required energy for cellular function and communication but also participates in balancing the levels of oxidative stress in neurons. Defects in glucose metabolism have been described in neurodegenerative disease; however, it remains unclear how this fundamental process contributes to neuronal cell death in these disorders. Here, we investigated the molecular mechanisms driving the selective neurodegeneration in an ataxic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s12035-018-1174-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oxford Parkinson's Disease Centre
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Grant:
J-1403 / Monument Trust Discovery Award
Medical Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Springer Publisher's website
Journal:
Molecular Neurobiology Journal website
Publication date:
2018-06-15
Acceptance date:
2018-06-01
DOI:
EISSN:
1559-1182
ISSN:
0893-7648
Pubs id:
pubs:858623
URN:
uri:1e0a7b6a-25aa-48c7-8e2f-89ca08fe97ad
UUID:
uuid:1e0a7b6a-25aa-48c7-8e2f-89ca08fe97ad
Local pid:
pubs:858623

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