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Journal article

Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases

Abstract:

The metastasis of tumors to bone is known to be promoted by prostaglandin E2 (PGE2) produced by the tumor host stromal tissue. Although bone metastases frequently occur in prostate cancer patients, the significance of PGE2 in stromal responses to the tumor is not known. In this study, we report that PGE2 and its receptor EP4 play a pivotal role in bone destruction and metastasis in an experimental metastasis model of prostate cancer in nude mice. Using human prostate cancer PC-3 cells that ar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbrc.2016.07.075

Authors


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Arthritis Research UK More from this funder
Cancer Research UK More from this funder
Institute of Global Innovation Research in TUAT More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biochemical and Biophysical Research Communications Journal website
Volume:
478
Issue:
1
Pages:
154-161
Publication date:
2016-07-19
Acceptance date:
2016-07-18
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Pmid:
27450806
Source identifiers:
636513
Language:
English
Keywords:
Pubs id:
pubs:636513
UUID:
uuid:1e03df3f-d7df-43c0-884e-d344cba42ccc
Local pid:
pubs:636513
Deposit date:
2016-10-17

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