Journal article
Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases
- Abstract:
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The metastasis of tumors to bone is known to be promoted by prostaglandin E2 (PGE2) produced by the tumor host stromal tissue. Although bone metastases frequently occur in prostate cancer patients, the significance of PGE2 in stromal responses to the tumor is not known. In this study, we report that PGE2 and its receptor EP4 play a pivotal role in bone destruction and metastasis in an experimental metastasis model of prostate cancer in nude mice. Using human prostate cancer PC-3 cells that ar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 153.2KB)
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- Publisher copy:
- 10.1016/j.bbrc.2016.07.075
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Authors
Funding
Arthritis Research UK
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Cancer Research UK
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Institute of Global Innovation Research in TUAT
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochemical and Biophysical Research Communications Journal website
- Volume:
- 478
- Issue:
- 1
- Pages:
- 154-161
- Publication date:
- 2016-07-19
- Acceptance date:
- 2016-07-18
- DOI:
- EISSN:
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1090-2104
- ISSN:
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0006-291X
- Pmid:
-
27450806
- Source identifiers:
-
636513
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:636513
- UUID:
-
uuid:1e03df3f-d7df-43c0-884e-d344cba42ccc
- Local pid:
- pubs:636513
- Deposit date:
- 2016-10-17
Terms of use
- Copyright holder:
- © 2016 Published by Elsevier Inc
- Copyright date:
- 2016
- Notes:
- © 2016 Published by Elsevier Inc. This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.bbrc.2016.07.075
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