Journal article
Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.
- Abstract:
-
The mouse mutant Doublefoot (Dbf) shows preaxial polydactyly with 6-9 triphalangeal digits in all four limbs and additional abnormalities including a broadened skull, hydrocephalus, and a thickened, kinked tail. The autopod undergoes a characteristic expansion between late embryonic day (E) 10.5 and E11.5, following the onset of ectopic Indian hedgehog (Ihh) expression in the entire distal mesenchyme, except for the zone of polarising activity (ZPA), at E10.5. We show here that limb prepatter...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.mod.2008.01.001
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Bibliographic Details
- Journal:
- Mechanisms of development
- Volume:
- 125
- Issue:
- 5-6
- Pages:
- 517-526
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
-
1872-6356
- ISSN:
-
0925-4773
- Source identifiers:
-
119617
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:119617
- UUID:
-
uuid:1dfaa9fd-6475-4fe2-8c40-972c228507a4
- Local pid:
- pubs:119617
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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