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Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.

Abstract:

The mouse mutant Doublefoot (Dbf) shows preaxial polydactyly with 6-9 triphalangeal digits in all four limbs and additional abnormalities including a broadened skull, hydrocephalus, and a thickened, kinked tail. The autopod undergoes a characteristic expansion between late embryonic day (E) 10.5 and E11.5, following the onset of ectopic Indian hedgehog (Ihh) expression in the entire distal mesenchyme, except for the zone of polarising activity (ZPA), at E10.5. We show here that limb prepatter...

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Publication status:
Published

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Publisher copy:
10.1016/j.mod.2008.01.001

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Mechanisms of development
Volume:
125
Issue:
5-6
Pages:
517-526
Publication date:
2008-01-01
DOI:
EISSN:
1872-6356
ISSN:
0925-4773
URN:
uuid:1dfaa9fd-6475-4fe2-8c40-972c228507a4
Source identifiers:
119617
Local pid:
pubs:119617

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