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Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis

Abstract:

We have analysed data on exacerbation rates, Expanded Disability Status Scale (EDSS) scores, and lesion burdens using the results of two neutralizing antibody (NAB) assays (CPE and MxA) from the pivotal relapsing-remitting multiple sclerosis (MS) trial of interferon beta-1b (IFNB) with a longitudinal approach, where the influence of NABs in individual patients is assessed by comparing responses during NAB-positive and NAB-negative periods. There are apparent influences on exacerbation rate re...

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Publisher copy:
10.1191/1352458504ms1004oa

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Multiple Sclerosis More from this journal
Volume:
10
Issue:
2
Pages:
126-138
Publication date:
2004-04-01
DOI:
ISSN:
1352-4585
Language:
English
Keywords:
Pubs id:
pubs:328885
UUID:
uuid:1df9cc28-54d0-4335-9604-f62f8146dfc6
Local pid:
pubs:328885
Source identifiers:
328885
Deposit date:
2013-11-16

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