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Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.

Abstract:

The antigenic diversity of human immunodeficiency virus type 1 (HIV-1) represents a significant challenge for vaccine design as well as the comprehensive assessment of HIV-1-specific immune responses in infected persons. In this study we assessed the impact of antigen variability on the characterization of HIV-1-specific T-cell responses by using an HIV-1 database to determine the sequence variability at each position in all expressed HIV-1 proteins and a comprehensive data set of CD8 T-cell ...

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Authors


Altfeld, M More by this author
Shankarappa, R More by this author
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Journal:
Journal of virology
Volume:
77
Issue:
13
Pages:
7330-7340
Publication date:
2003-07-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1df877f2-8491-4e55-a7a4-081bb7d6aeba
Source identifiers:
191078
Local pid:
pubs:191078

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