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Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141 XCR1 dendritic cells

Abstract:

Monocyte-derived dendritic cells (moDC) have been widely used in cancer immunotherapy but show significant donor-to-donor variability and low capacity for the cross-presentation of tumour-associated antigens (TAA) to CD8 T cells, greatly limiting the success of this approach. Given recent developments in induced pluripotency and the relative ease with which induced pluripotent stem (iPS) cell lines may be generated from individuals, we have succeeded in differentiating dendritic cells (DC) fr...

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Publisher copy:
10.1038/gt.2011.177

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Journal:
Gene Therapy
Volume:
19
Issue:
10
Pages:
1035-1040
Publication date:
2012-10-01
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Source identifiers:
356637
Language:
English
Keywords:
Pubs id:
pubs:356637
UUID:
uuid:1df21f2d-8d1f-4ebf-8cff-31442a2c95fb
Local pid:
pubs:356637
Deposit date:
2013-11-16

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