Journal article
Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift
- Abstract:
- Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, 962.6KB)
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- Publisher copy:
- 10.1021/acs.joc.9b01345
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Authors
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Organic Chemistry Journal website
- Volume:
- 84
- Issue:
- 15
- Pages:
- 9671–9683
- Publication date:
- 2019-07-05
- Acceptance date:
- 2019-07-05
- DOI:
- EISSN:
-
1520-6904
- ISSN:
-
0022-3263
- Pmid:
-
31276419
- Source identifiers:
-
1028459
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1028459
- UUID:
-
uuid:1df10e2e-d326-4c94-91fe-380f5d3a3577
- Local pid:
- pubs:1028459
- Deposit date:
- 2019-07-08
Terms of use
- Copyright holder:
- ACS
- Copyright date:
- 2019
- Rights statement:
- Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
- Notes:
- This is the accepted manuscript version of the article. The final version is available from American Chemical Society at: https://doi.org/10.1021/acs.joc.9b01345
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