Journal article icon

Journal article

Spirocyclic tetramates by sequential Knoevenagel and [1,5]-prototropic shift

Abstract:
Highly functionalised spirocyclic tetramates were prepared via tert-amino reaction of bicyclic tetramates. While these compounds isomerise in solution, stable analogues can be prepared via appropriate choice of substituents. Further modification of these compounds allows for introduction of aromatic groups, making them suitable as skeletal suitable for application in medicinal chemistry.
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.joc.9b01345

Authors


More by this author
Institution:
University of Oxford
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-8258-860X
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
St Peter's College
Role:
Author
ORCID:
0000-0002-4440-3632
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Organic Chemistry Journal website
Volume:
84
Issue:
15
Pages:
9671–9683
Publication date:
2019-07-05
Acceptance date:
2019-07-05
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
Pmid:
31276419
Source identifiers:
1028459
Language:
English
Keywords:
Pubs id:
pubs:1028459
UUID:
uuid:1df10e2e-d326-4c94-91fe-380f5d3a3577
Local pid:
pubs:1028459
Deposit date:
2019-07-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP