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Thesis

HIV-1 transmission between T cells and macrophages: consequences for viral pathogenesis.

Abstract:

Within the paradigm of HIV-1 infection, macrophages play a crucial role as long-lived viral reservoirs. However, cell-free virus infection is inefficient and is unlikely to explain the levels of infection observed in vivo. To investigate the hypothesis that macrophages might be infected via direct contact with HIV-1-infected T cells, macrophage and HIV-1-infected T cell cocultures were imaged in real time. I observed that macrophages preferentially phagocytosed HIV-1-infected T ce...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Sattentau Lab
Oxford college:
Lincoln College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Baxter, A
Grant:
089577/Z/09/Z
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1df105a3-1f0d-4159-8e01-3fdb231a0c42
Local pid:
ora:8964
Deposit date:
2014-09-19

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