Journal article icon

Journal article

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Abstract:

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional ge...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1038/ncomms15034

Authors


More from this funder
Name:
Department of Health
Grant:
NF-SI-0512-10114
More from this funder
Name:
NCI NIH HHS
Grant:
HHSN261200800001E
UM1 CA182934
P30 CA023108
P50 CA062924
R01 CA154823
U01 CA164947
UM1 CA167462
More from this funder
Name:
CCR NIH HHS
Grant:
HHSN261200800001C
More from this funder
Name:
Medical Research Council
Grant:
G0401527
G1000143
MR/N003284/1
More from this funder
Name:
Cancer Research UK
Grant:
14136
19167
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
8
Article number:
15034
Publication date:
2017-04-27
Acceptance date:
2017-02-23
DOI:
ISSN:
2041-1723
Pmid:
28447668
Language:
English
Keywords:
Pubs id:
pubs:813554
UUID:
uuid:1de74321-8215-4033-9da6-fe9a71e3730a
Local pid:
pubs:813554
Source identifiers:
813554
Deposit date:
2019-02-28

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP