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Localisation and semi-quantitative measurement of lipocortin 1 in rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy.

Abstract:

Lipocortin 1 (LC1, also called annexin 1), a Ca2(+)- and phospholipid-binding protein, is an important mediator of glucocorticoid action in the anterior pituitary gland. Previous studies based on immunoprecipitation and Western blot analysis suggest that LC1 is found intracellularly both in the cytoplasm and in association with membranes and also on the cell surface where it attaches to the membrane by a Ca2(+)-dependent mechanism. However, as yet it is unclear which anterior pituitary cell t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Flower, RJ More by this author
Morris, JF More by this author
Buckingham, JC More by this author
Journal:
Journal of neuroendocrinology
Volume:
11
Issue:
9
Pages:
707-714
Publication date:
1999-09-05
DOI:
EISSN:
1365-2826
ISSN:
0953-8194
URN:
uuid:1dd9a349-483b-4c1d-bdfe-da55d70ee65e
Source identifiers:
114463
Local pid:
pubs:114463

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