Journal article
The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection.
- Abstract:
-
Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether distinct signalling pathways are induced in DP thymocytes as compared to mature T cells upon stimulation with antigen. Using triple transgenic mice expressing a TCR transgene, dominant negative ras/Mek proteins and a reporter gene construct with AP-1 or NF-kappa B binding sites, we showed a complete lack of transcriptional activity of NF-kappa...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/sj.cdd.4400760
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Bibliographic Details
- Journal:
- Cell death and differentiation
- Volume:
- 7
- Issue:
- 12
- Pages:
- 1253-1262
- Publication date:
- 2000-12-01
- DOI:
- EISSN:
-
1476-5403
- ISSN:
-
1350-9047
- Source identifiers:
-
2783
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:2783
- UUID:
-
uuid:1dd740b8-9dac-49f3-91ee-60d3989d9a0d
- Local pid:
- pubs:2783
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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