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Journal article

The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection.

Abstract:

Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether distinct signalling pathways are induced in DP thymocytes as compared to mature T cells upon stimulation with antigen. Using triple transgenic mice expressing a TCR transgene, dominant negative ras/Mek proteins and a reporter gene construct with AP-1 or NF-kappa B binding sites, we showed a complete lack of transcriptional activity of NF-kappa...

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Publication status:
Published

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Publisher copy:
10.1038/sj.cdd.4400760

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Cell death and differentiation
Volume:
7
Issue:
12
Pages:
1253-1262
Publication date:
2000-12-01
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
Source identifiers:
2783

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